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Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
Published on: December 8, 2010
A Clinicoepidemiological Study of Pediatric Cutaneous Leishmaniasis in Sinjar Province, Iraq
1Infectious Disease Unit, Azadi Teaching Hospital and College of Medicine, University of Zakho, Duhok, Iraq.
Insights
Intralesional injections of sodium stibogluconate showed a 99% success rate for treating cutaneous leishmaniasis (CL) in young children. Treatment effectiveness was linked to the number of doses per lesion, not patient factors.
Area of Science:
- * Infectious Diseases
- * Pediatric Dermatology
- * Parasitology
Background:
- * Cutaneous leishmaniasis (CL) poses a significant global health challenge, particularly affecting children.
- * Current pediatric CL treatment protocols often rely on adult efficacy data, highlighting a need for child-specific evaluations.
Purpose of the Study:
- * To assess the treatment outcomes of cutaneous leishmaniasis in preschool-aged children.
- * To identify factors influencing treatment success in this pediatric population.
Main Methods:
- * A cohort of 294 children diagnosed with CL in Sinjar Province, Iraq, between December 2018 and March 2019.
- * Treatment involved intralesional injections of sodium stibogluconate.
- * Patients were monitored for 3 months post-treatment completion.
Main Results:
- * A high treatment success rate of 99% (291/294) was achieved.
- * A significant correlation was observed between the number of doses administered per lesion and the total number of lesions (P = 0.002).
- * No significant associations were found between treatment outcome and lesion count, age, gender, or livestock ownership.
Conclusions:
- * Intralesional sodium stibogluconate demonstrates high efficacy for treating CL in preschool-aged children.
- * The number of lesions and the required doses per lesion are key factors in treatment response.
- * Further research is warranted to explore treatment indicators, including Leishmania genotype.
Abstract:
Cutaneous leishmaniasis (CL) is a major health problem worldwide. Although CL is a common disease among children, treatment regimens for the pediatric age group are based on extrapolation of efficacy data in adults. The present study aimed to evaluate the treatment outcome of CL in preschool-age children and the factors influencing the outcome. Two hundred ninety-four children were diagnosed with CL between December 2018 and March 2019 in Sinjar Province, Iraq. All patients were treated with intralesional injections of sodium stibogluconate and followed up for 3 months after the completion of treatment. The treatment success rate was 99% (291/294). A statistically significant association was found between the number of doses per lesion and the number of lesions (P = 0.002; CI = 0.066-0.2875). No association was found between the number of lesions, age, gender, or the presence of livestock and the treatment outcome. In conclusion, treatment success rate was high with the use of intralesional injection of sodium stibogluconate. A significant association was found between the number of lesions and the number of doses. Further studies are required to assess the treatment outcome indicators, including the genotype of leishmania.
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