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Updated: Jan 19, 2026

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Exercise-induced syncope and Brugada syndrome.

Anjan S Batra1, Rachel Watson2, Anthony C McCanta1

  • 1Department of Pediatric Cardiology, University of California-Irvine and Children's Hospital of Orange County, Orange CA, USA.

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Summary

Brugada syndrome (BrS) can cause sudden cardiac death. This case shows exercise stress tests may help diagnose BrS and identify at-risk patients, challenging the notion that exercise is not a trigger.

Keywords:
Brugada syndromeexercisetreadmill stress testingventricular fibrillation

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Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Brugada syndrome (BrS) is an inherited cardiac condition associated with ST elevation and life-threatening arrhythmias.
  • Arrhythmias in BrS typically manifest at rest, during fever, or vagotonic states.
  • Exercise is generally not considered a precipitating factor for arrhythmias in BrS patients.

Observation:

  • A patient presented with syncope and ventricular tachycardia during an exercise stress test.
  • The patient was confirmed to be genotypically and phenotypically positive for Brugada syndrome.

Findings:

  • This case demonstrates exercise can induce symptoms and arrhythmias in Brugada syndrome.
  • Exercise stress testing identified a patient with previously unrecognized BrS.

Implications:

  • Exercise stress testing may play a crucial role in diagnosing Brugada syndrome.
  • This diagnostic approach could aid in risk stratification for specific BrS patient populations.
  • Revisiting the role of exercise as a potential trigger in Brugada syndrome is warranted.