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Jamming state transition and collective cell migration.

Ivana Pajic-Lijakovic1, Milan Milivojevic1

  • 1Faculty of Technology and Metallurgy, Belgrade University, Karnegijeva 4, Belgrade, Serbia.

Journal of Biological Engineering
|September 14, 2019
PubMed
Summary

Jamming state transition in collective cell migration is clarified rheologically. This non-linear viscoelastic solid state is characterized by infinite relaxation time and suppressed cell migration, but can be overcome in subsequent cycles.

Keywords:
Collective cell migrationJamming state transitionLong-time cell rearrangementTissue surface tensionViscoelasticity of multicellular surfaces

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Area of Science:

  • Biophysics
  • Rheology
  • Cell Biology

Background:

  • Collective cell migration involves transitions between migrating and resting states, often described as jamming.
  • Existing literature lacks rheological confirmation for jamming state transitions in cell migration.
  • Yield stress indicates liquid-to-solid transitions but not specifically jamming.

Purpose of the Study:

  • To define the jamming state rheologically.
  • To formulate a constitutive model for the jamming state.
  • To analyze jamming state transitions in multicellular systems during collective cell migration.

Main Methods:

  • Formulation of a constitutive model for jamming state based on damped constituent migration (zero diffusion coefficient), infinite relaxation time, and specific storage and loss moduli ratio (G'/G'' = const > 1).
  • Analysis of cell aggregate rounding after uniaxial compression as a model system.
  • Examination of literature data on collective cell migration and relaxation cycles.

Main Results:

  • The jamming state is identified as a non-linear viscoelastic solid state where the system cannot relax.
  • Three scenarios of cell migration (ordered, disordered, and suppressed) were established based on mechanical and biochemical perturbations.
  • Highly suppressed cell migration under large perturbations corresponds to the jamming state.

Conclusions:

  • The jamming state is rheologically defined by specific conditions including infinite relaxation time.
  • Collective cell migration can exhibit jamming, characterized by suppressed cell movement.
  • Multicellular systems can overcome the jamming state in subsequent relaxation cycles.