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Asymptomatic ceftriaxone-associated pseudolithiasis.

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Area of Science:

  • Internal Medicine
  • Pharmacology

Background:

  • A case study involving an 88-year-old female patient with a history of meningioma and dementia.
  • The patient presented with symptoms suggestive of a urinary tract infection.

Observation:

  • Initial treatment with ceftriaxone improved urinary symptoms.
  • A gallbladder stone was detected via CT scan on hospital day 28, despite the absence of abdominal discomfort.
  • The patient experienced recurrent high fever.

Findings:

  • Ceftriaxone was suspected as the cause of pseudolithiasis (gallbladder sludge mimicking stones).
  • Switching to cefmetazole led to a reduction in the size of the gallbladder stone.
  • Pseudolithiasis can occur asymptomatically.

Implications:

  • Clinicians should consider ceftriaxone-associated pseudolithiasis in patients presenting with unexplained fever and gallbladder findings.
  • Patient history, including medication use and seasonality, is crucial for accurate diagnosis.
  • This case underscores the importance of vigilant monitoring for adverse drug reactions.