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Related Concept Videos

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications05:26

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Related Experiment Video

Updated: Jan 19, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
05:26

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Liquid biopsy for lung cancers: an update on recent developments.

Alberto E Revelo1, Alvaro Martin2, Ricardo Velasquez2

  • 1Division of Pulmonary, Critical Care and Sleep Medicine, Interventional Pulmonology Section, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Annals of Translational Medicine
|September 14, 2019
PubMed
Summary

Liquid biopsy is becoming a key tool for lung cancer management, aiding in early detection and monitoring. This review covers biomarkers and their role in current clinical practice for lung cancer.

Keywords:
Blood specimen collectioncirculating tumor DNA (ctDNA)liquid biopsylung neoplasm

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Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Liquid biopsy is an emerging technology in lung cancer care.
  • It offers potential benefits for screening, early detection, monitoring, and prognostication.
  • Established guidelines and expert recommendations support its clinical adoption in specific scenarios.

Purpose of the Study:

  • To review the current data on various biomarkers used in liquid biopsy for lung cancer.
  • To provide an overview of how these biomarkers are utilized in clinical practice.
  • To highlight the evolving role of liquid biopsy in lung cancer management.

Main Methods:

  • Review of existing literature and clinical data on liquid biopsy biomarkers in lung cancer.
  • Analysis of biomarker performance and clinical utility.
  • Synthesis of information regarding current adoption and future potential.

Main Results:

  • Liquid biopsy offers valuable tumor genomic information.
  • Several biomarkers are under active investigation for lung cancer applications.
  • Specific clinical scenarios demonstrate the active adoption of liquid biopsy.

Conclusions:

  • Liquid biopsy is a valuable complementary tool in lung cancer management.
  • Understanding specific biomarkers is crucial for optimizing its clinical use.
  • Continued research will further refine the application of liquid biopsy in lung cancer.