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Related Experiment Video

Updated: Jan 19, 2026

Perspectives on Neuroscience
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A retrieval analysis perspective on revision for infection.

Michael A Kokko1, Matthew P Abdel2, Daniel J Berry2

  • 1Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.

Arthroplasty Today
|September 14, 2019
PubMed
Summary

Retrieval analysis reveals prosthetic joint infection (PJI) is a significant cause of revision arthroplasty, often occurring sooner in revision implants. Studies with short follow-up may under-report late PJI cases.

Keywords:
EpidemiologyOrthopaedic retrieval analysisProsthesis-related infectionsProsthetic joint infectionStatistics

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Area of Science:

  • Orthopaedic surgery
  • Biomaterials science
  • Infectious disease

Background:

  • Retrieval analysis is crucial for understanding orthopaedic implant failure.
  • The role of retrieval studies in characterizing prosthetic joint infection (PJI) is not well-established.
  • This study investigates if retrieval data aligns with clinical PJI timelines.

Purpose of the Study:

  • To analyze explanted hip and knee components over a decade.
  • To determine the frequency of infection as a reason for revision arthroplasty.
  • To assess factors influencing indwelling time and temporal patterns of infected explants.

Main Methods:

  • Examined 2527 explanted hip and knee components.
  • Quantified infection as a cause of revision arthroplasty.
  • Analyzed indwelling times based on joint type, revision status, and reason for retrieval.

Main Results:

  • Infection accounted for 20% of explants.
  • Infected prostheses were removed significantly sooner than non-infected ones.
  • Revision components were removed sooner than primary components.
  • Observed temporal distributions suggest later PJI onset than in short-term clinical studies.

Conclusions:

  • Prosthetic joint infection is a major driver of revision arthroplasty.
  • Infected revision components have shorter indwelling times than primary components.
  • Clinical studies with <10 years follow-up may underestimate late PJI incidence.