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A case report of Morvan syndrome
1Fırat University, Departmant of Neurology, Elazığ, Turkey.
Morvan syndrome, a rare autoimmune disorder, presents with nerve hyperexcitability and encephalopathy. Early diagnosis and treatment with immunotherapy can lead to remission, but long-term malignancy surveillance is crucial.
Area of Science:
- Neurology
- Immunology
- Rare Diseases
Background:
- Morvan syndrome is a rare autoimmune neurological disorder.
- It is characterized by peripheral nerve hyperexcitability, encephalopathy, dysautonomia, and insomnia.
Observation:
- A patient presented with confusion, myokymia, hyperhidrosis, seizures, tachycardia, agitation, hypokalemia, and hyponatremia.
- Cranial MRI revealed medial temporal and insular lobe hyperintensities.
- Electromyography confirmed peripheral nerve hyperreactivity.
Findings:
- Contactin-associated protein-like 2 (CASPR2) and leucine-rich glioma inactivated protein 1 (LGI1) antibodies were positive.
- The patient was diagnosed with Morvan syndrome.
- Treatment with intravenous immunoglobulin and corticosteroids resulted in near-complete remission.
Implications:
- Morvan syndrome presents diagnostic and therapeutic challenges.
- Remission is achievable with appropriate treatment.
- Long-term monitoring for malignancies is recommended in affected patients.
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