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Updated: Jan 19, 2026
Animal Diversity: Form and Function of Crickets and Crayfish - Concept
Stabilization of Transient 3-Chloroindolenines Enables Diverse Functionalization
Ranran Cui1, Jinxiang Ye1, Wenhui Mo1
1Key Laboratory of Molecule Synthesis and Function Discovery (Fuzhou University), Fujian Province University, College of Chemistry , Fuzhou University , Fuzhou , Fujian 350116 , China.
Abstract:
Transient intermediates as highly reactive species are difficult to manipulate due to their poor stability. Stabilization of unstable intermediates for functionalization is an attractive approach, but the practical applications are still rare. Herein, we explore a strategy that could effectively stabilize labile 3-chloroindolenines and significantly improve the lifetime from seconds to weeks. This chemistry was utilized to enable the synthesis of 55 diverse compounds which are unable to be achieved by traditional approach.
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