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Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
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Clinical pattern of hemophilia and causes of variability

Maria Eva Mingot-Castellano1

  • 1Department of Hematology, Málaga Regional University Hospital, Malaga, Spain.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|September 14, 2019
PubMed

: In persons with hemophilia, the severity and spontaneity of bleeding episodes depends on the degree of factor deficiency present in the patients. Severe hemophilia is classically characterized by a factor VIII (FVIII) or factor IX (FIX) coagulant activity below 1% of normal (spontaneous and severe bleeds). Moderate hemophilia is associated with factor activity between 1 and 5% of normal (milder spontaneous and traumatic bleeds). Finally, mild hemophilia has factor activity in excess of 5% of normal (traumatic bleeds in general). Nonetheless, this classification is rather simplistic. It is a known fact that there are subjects with identical clotting factor levels who have different bleeding phenotypes. We will analyze different factors to justify this.

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