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Related Concept Videos

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

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Here, we present optimized tissue-clearing protocols to image the murine aorta in three dimensions (3D). We delineate state-of-the-art procedures for immunostaining, optical clearing, and imaging with the intent to define the anatomical proximity of the peripheral nervous system with atherosclerotic plaques and the adventitia in...
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We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy...
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The method presented here uses simultaneous positron emission tomography and magnetic resonance imaging. In the cerebral hypoxia-ischemia model, dynamic changes in diffusion and glucose metabolism occur during and after injury. The evolving and irreproducible damage in this model necessitates simultaneous acquisition if meaningful multi-modal imaging data are to be...
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Here, we present a protocol to create orthotopic hepatocellular carcinoma xenografts with and without hepatic artery ligation and perform non-invasive positron emission tomography (PET) imaging of tumor hypoxia using [18F]Fluoromisonidazole ([18F]FMISO) and [18F]Fluorodeoxyglucose...
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Related Experiment Video

Updated: Jan 19, 2026

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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Atherosclerosis imaging using PET: Insights and applications.

Rouchelle S Sriranjan1, Jason M Tarkin1, Nicholas R Evans1

  • 1Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.

British Journal of Pharmacology
|September 14, 2019
PubMed
Summary

Positron emission tomography (PET) imaging reveals high-risk plaque features. Novel PET tracers and techniques enhance the characterization of vulnerable atherosclerotic plaque for improved cardiovascular disease management.

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Area of Science:

  • Cardiovascular Imaging
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Atherosclerotic plaque rupture is a major cause of cardiovascular events.
  • Identifying vulnerable plaques is crucial for risk stratification and treatment.
  • Current imaging modalities have limitations in characterizing plaque instability.

Purpose of the Study:

  • To review the role of PET imaging in atherosclerosis.
  • To highlight current and emerging PET radiotracers for plaque characterization.
  • To discuss the application of PET imaging in cardiovascular drug development.

Main Methods:

  • Review of existing literature on PET imaging in atherosclerosis.
  • Focus on radiotracers targeting inflammation, hypoxia, and neoangiogenesis.
  • Discussion of imaging protocols and hybrid scanner advancements.

Main Results:

  • 18F-fluorodeoxyglucose (18F-FDG) is a key PET tracer for plaque inflammation.
  • Other PET tracers target microcalcification, hypoxia, and neoangiogenesis.
  • PET imaging provides valuable endpoints for cardiovascular interventional trials.

Conclusions:

  • PET imaging offers a powerful tool for characterizing high-risk atherosclerotic plaques.
  • Advancements in PET tracers and technology promise more accurate plaque assessment.
  • PET imaging plays an increasingly important role in cardiovascular drug development.