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Updated: Jan 19, 2026

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Published on: February 24, 2018
Perfluoro Alkyl Hypofluorites and Peroxides Revisited
Jan H Nissen1, Thomas Drews1, Benjamin Schröder1
1Fachbereich für Biologie, Chemie, Pharmazie, Institut für Chemie und Biochemie-Anorganische Chemie, Freie Universität Berlin, Fabeckstraße 34/36, 14195, Berlin, Germany.
Abstract:
A more convenient synthesis of the perfluoro alkyl hypofluorite (F3 C)3 COF as well as the hitherto unknown (C2 F5 )(F3 C)2 COF compound is reported. Both hypofluorites can be prepared by use of the corresponding tertiary alcohols RF OH and elemental fluorine in the presence of CsF. An appropriate access to these highly reactive hypofluorites is crucial. The hypofluorites are then transferred into their corresponding perfluoro bisalkyl peroxides RF OORF [RF =(F3 C)3 C, (C2 F5 )(F3 C)2 C] by treatment with partially fluorinated silver wool. NMR, gas-phase infrared, and solid-state Raman spectra of the perfluoro bisalkyl peroxides are presented and their chemical properties are discussed.
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