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Updated: Jan 19, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
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Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

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Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.

Farshad C Azimi1, Jeffrey E Lee1

  • 1Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Protein Science : a Publication of the Protein Society
|September 14, 2019
PubMed
Summary

Human immunodeficiency virus (HIV) uses the viral infectivity factor (Vif) protein to degrade APOBEC3 (A3) restriction factors, which normally inhibit viral replication. This review analyzes structural and biochemical data to understand Vif-A3 interactions.

Keywords:
APOBEC3HIVlentivirusprotein-protein interactionsrestriction factorviral infectivity factor

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