Antioxidant activity of a polysaccharide produced by Chaetomium globosum CGMCC 6882

In present work, a polysaccharide (GCP-WS) was successfully produced by Chaetomium globosum CGMCC 6882 from wheat straw. Monosaccharide composition of GCP-WS was rhamnose, glucosamine, galactose, glucose, xylose, fructose and glucuronic acid in a molar ratio of 21.46:1.58:1.11:55.15:36.37:7.04:7.34. Meanwhile, molecular weight of GCP-WS was 3.538 × 10⁴ Da with a polydispersity of 1.043. Antioxidant assays revealed GCP-WS had strong scavenging effects on DPPH radical, ABTS radical, superoxide anions and hydroxyl radical in a dose-dependent manner. Results displayed that at the concentration of 5 mg/mL, the corresponding scavenging abilities of GCP-WS reached 83.08 ± 2.58%, 85.69 ± 1.62%, 79.38 ± 2.03% and 81.39 ± 1.47%, respectively. GCP-WS shows the potential for development as an effective antioxidant agent.