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Updated: Jan 19, 2026

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Published on: July 5, 2022
Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease
A Carrër1, S Turban2, N Provost2
1PSL Research University, Chimie ParisTech-CNRS, Institut de Recherche de Chimie Paris, 11 rue P. et M. Curie, 75005 Paris, France.
Abstract:
The first total synthesis of juniperanol, the tricyclic sesquiterpenoid enantiomer of α-cedrol is described. The synthesis relies on stereoselective gold-catalyzed Ohloff-type propargylic ester rearrangement performed on a 10 g scale, and a carbocationic cascade in the presence of acetyl methanesulfonate. The ability of juniperanol to interfere in glucose processes in different cell types is described.
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