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Updated: Jan 19, 2026

Phosphodiester Linkages and Nucleotides
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Phosphodiester Linkages and Nucleotides

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Using database linkages to measure innovation, commercialization, and survival of small businesses

James Onken1, Andrew C Miklos2, Travis F Dorsey3

  • 1Research Enterprise Analytics, LLC, 21 Hardwicke Place, Rockville, MD 20850, USA.

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Phosphodiester Linkages01:01

Phosphodiester Linkages

Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
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