BioMOF@cellulose fabric composites for bioactive molecule delivery

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• Developing advanced materials for controlled drug delivery is crucial for effective wound healing and cancer therapy.
• Metal-Organic Frameworks (MOFs) offer tunable properties for drug encapsulation and release.
• Cellulose fabrics provide a biocompatible and versatile platform for material integration.

Purpose of the Study:

• To synthesize and characterize a zinc glutamate Bio Metal-Organic Framework (BioMOF) on cellulose fabric.
• To investigate the dual controlled delivery of nitric oxide (NO) and 5-fluorouracil (5FU) from the BioMOF@cellulose composite.
• To evaluate the antibacterial and anticancer efficacy of the developed material for wound and skin cancer applications.

Main Methods:

• In situ synthesis of BioMOF on cotton fabric.
• Characterization using XRPD, FTIR-ATR, FESEM, UV-Vis-NIR, XPS, TGA, N2 adsorption, and GC-MS.
• Assessment of antibacterial and anticancer activity against melanoma skin cells.

Main Results:

• Successful in situ synthesis of BioMOF@cellulose fabric composite.
• Demonstrated controlled release of NO and 5FU.
• Fe(II) doping enhanced NO incorporation into the BioMOF.
• Significant antibacterial and anticancer activity observed in vitro.

Conclusions:

• BioMOF@cellulose fabric composites are effective for dual controlled delivery of NO and 5FU.
• The material exhibits potential for advanced wound care and skin cancer treatment.
• This approach offers a promising strategy for developing functional textiles for biomedical applications.