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Updated: Jan 19, 2026
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Eco-friendly ultrasonic assisted liquid-liquid microextraction method based on hydrophobic deep eutectic solvent for
Yinghe Ji1, Zhaorui Meng1, Jing Zhao1
1School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, 110016, Shenyang, Liaoning Province, China.
Abstract:
A sensitive, fast, eco-friendly ultrasound assisted liquid-liquid microextraction (LLME) in combination with hydrophobic deep eutectic solvent (DES) method was developed to preconcentrate and extract sulfonamides in fruit juices, prior to high-performance liquid chromatographic (HPLC) analysis. The DES was synthesized with trioctylmethylammonium chloride (TAC) and 2-octanol at the molar ratio of 1:2. Some parameters which affected the extraction efficiency were investigated and optimized, including the volume of DES, extraction method, extraction time, pH. Under the optimum conditions, good linearity (r = 0.9999) in the range of 0.1-50 µg mL-1 was obtained. The limit of detection (LOD) was 0.02-0.05 µg mL-1. And the accuracy of the developed method was confirmed by analysis of spike method, the recoveries were in the range of 88.09-97.84% at the spike levels of 2-20 µg mL-1 in fruit juices.
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