Related Experiment Video
Updated: Jan 19, 2026
01:26
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
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Renin-Angiotensin Inhibition in Combating Malignancy: A Review.
Talma Rosenthal1, Irene Gavras2
1Department of Physiology and Pharmacology, Hypertension Research Unit, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel rtalma@tauex.tau.ac.il.
Anticancer Research
|September 15, 2019
Summary
Angiotensin-converting enzyme inhibitors (ACEIs) show a protective association with cancer prognosis and may improve outcomes when used with chemotherapy. Further research is needed to understand their anti-tumor mechanisms.
Area of Science:
- Oncology
- Pharmacology
- Epidemiology
Background:
- Previous literature reviews until 2000 found conflicting evidence on the link between ACEIs and cancer development.
- Inconclusive results necessitated further investigation into ACEIs' potential role in malignancy.
- Experimental studies were needed to elucidate the mechanisms of renin-angiotensin system blockers on tumor growth.
Purpose of the Study:
- To review recent human clinical studies from the past two decades on ACEI treatment and cancer prognosis.
- To evaluate the protective association between ACEI treatment and patient outcomes in various cancer types.
- To assess the role of ACEI/angiotensin receptor blockers as adjuvant therapy in cancer treatment.
Main Methods:
- Comprehensive review of human clinical studies, including large epidemiological, prospective, and retrospective studies.
- Analysis of data from the past 20 years focusing on ACEI treatment and cancer incidence, prognosis, and survival.
- Evaluation of synergistic effects of ACEI/angiotensin receptor blockers with chemotherapy.
Main Results:
- Recent evidence suggests a protective association between ACEI treatment and the prognosis of patients with specific cancer types.
- ACEI treatment correlates with improved patient outcomes, including progression-free and overall survival.
- ACEI/angiotensin receptor blockers demonstrate synergistic effects when used as adjuvant therapy with chemotherapy.
Conclusions:
- ACEI treatment is associated with a protective effect on cancer prognosis across various cancer types and stages.
- Combined therapy with ACEI/angiotensin receptor blockers and chemotherapy may enhance patient outcomes.
- Further research into the anti-tumor mechanisms of ACEIs warrants continued investigation.
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