Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior04:58

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior

645
The goal of the current protocol is to outline the steps necessary to establish and use a social preference assay for adult zebrafish and demonstrate that it can be used to characterize ethanol-induced social...
645
Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells (HSPCs) in Developing Zebrafish Embryos10:28

Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells (HSPCs) in Developing Zebrafish Embryos

8.3K
Here, we present a simple method to quantitate hematopoietic stem and progenitor cells (HSPCs) in embryonic zebrafish. HSPCs from dissociated zebrafish are plated in methylcellulose with supportive factors, differentiating into mature blood. This allows the detection of blood defects and allows drug screening to be easily...
8.3K
An Introduction to Modeling Behavioral Disorders and Stress10:17

An Introduction to Modeling Behavioral Disorders and Stress

19.6K
Recently, it has been discovered that behavioral conditions such as, depression, anxiety and stress-response have a neurological basis. Understanding the biological underpinnings of these conditions may help scientists in developing more effective therapies to treat these disorders. Typically, rodent models are used in this field and behavioral scientists create these models using interventions like drug administration or surgery. It is important to understand how to create and evaluate rodent...
19.6K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

9.2K
Renal injuries incurred from nephrotoxins, which include drugs ranging from antibiotics to chemotherapeutics, can result in complex disorders whose pathogenesis remains incompletely understood. This protocol demonstrates how zebrafish can be used for disease modeling of these conditions, which can be applied to the identification of renoprotective...
9.2K
A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish08:13

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

3.7K
We modified the Marmarou weight drop model for adult zebrafish to examine a breadth of pathologies following blunt-force traumatic brain injury (TBI) and the mechanisms underlying subsequent neuronal regeneration. This blunt-force TBI model is scalable, induces a mild, moderate, or severe TBI, and recapitulates injury heterogeneity observed in human...
3.7K
Zebrafish Model of Neuroblastoma Metastasis05:20

Zebrafish Model of Neuroblastoma Metastasis

3.2K
This paper introduces the method of developing, characterizing, and tracking in real-time the tumor metastasis in zebrafish model of neuroblastoma, specifically in the transgenic zebrafish line with overexpression of MYCN and LMO1, which develops metastasis spontaneously.
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration.

EMBO reports·2026
Same author

Predictive capacity of peritransplant measurable residual disease thresholds in NPM1-mutant acute myeloid leukemia.

Blood advances·2026
Same author

Ex vivo drug sensitivity testing predicts treatment outcomes in advanced ovarian cancer.

NPJ precision oncology·2026
Same author

Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes.

Nature microbiology·2026
Same author

Predictive capacity of peritransplant measurable residual disease thresholds in NPM1-mutant acute myeloid leukemia.

Blood advances·2025
Same author

Dual anti-CD19/22 and anti-BCMA CAR T-cell therapy in a patient with multiple myeloma and secondary B-ALL.

Blood advances·2025

Related Experiment Video

Updated: Jan 19, 2026

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior
04:58

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior

Published on: February 9, 2024

645

Modeling hematopoietic disorders in zebrafish.

Martina Konantz1, Christoph Schürch2, Pauline Hanns2

  • 1Department of Biomedicine, University of Basel and University Hospital Basel, Basel 4031, Switzerland martina.konantz@unibas.ch.

Disease Models & Mechanisms
|September 15, 2019
PubMed
Summary
This summary is machine-generated.

Zebrafish are valuable vertebrate models for studying blood development and diseases. This review covers zebrafish hematopoiesis and models of blood disorders, aiding translational research in human conditions.

Keywords:
Blood disordersBone marrow failure syndromeDisease modelsHematopoiesisImmunodeficiencyLeukemia

More Related Videos

Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells HSPCs in Developing Zebrafish Embryos
10:28

Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells HSPCs in Developing Zebrafish Embryos

Published on: November 30, 2017

8.3K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.2K

Related Experiment Videos

Last Updated: Jan 19, 2026

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior
04:58

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior

Published on: February 9, 2024

645
Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells HSPCs in Developing Zebrafish Embryos
10:28

Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells HSPCs in Developing Zebrafish Embryos

Published on: November 30, 2017

8.3K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.2K

Area of Science:

  • Hematology
  • Developmental Biology
  • Genetics

Background:

  • Zebrafish serve as a powerful vertebrate model for biological research.
  • Key advantages include genetic screening capabilities and in vivo cellular imaging.
  • Conserved blood development pathways facilitate translation to mammalian models.

Purpose of the Study:

  • To review zebrafish hematopoiesis.
  • To discuss current zebrafish models for blood disorders.
  • To highlight applications in translational research.

Main Methods:

  • Literature review of zebrafish hematopoiesis.
  • Analysis of existing zebrafish disease models.
  • Focus on model generation and translational utility.

Main Results:

  • Zebrafish models exist for myeloid/lymphoid malignancies, bone marrow failure, and immunodeficiencies.
  • These models leverage genetic screens and in vivo imaging.
  • Discoveries in zebrafish have translated to murine and human studies.

Conclusions:

  • Zebrafish are instrumental in understanding blood development and disease.
  • Zebrafish models offer significant potential for translational research.
  • Further application of these models can advance human hematological disease research.