Related Experiment Video
Updated: Jan 19, 2026
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Is There Currently a Place for Combined Mitral and Aortic Transcatheter Interventions?
Rodney De Palma1, Crochan J O'Sullivan2, Magnus Settergren2
1Heart and Vascular Theme, Karolinska University Hospital and Karolinska Institutet, SE-171 76, Stockholm, Sweden. rodney_de_palma@icloud.com.
Insights
Combined mitral and aortic valve disease, often degenerative, presents unique challenges. Transcatheter interventions show promise for treating this complex valvular disease, though more research is needed.
Area of Science:
- Cardiology
- Valvular Heart Disease
- Interventional Cardiology
Background:
- Combined mitral and aortic valvular disease affects up to 25% of adults with symptomatic valvular issues.
- The primary cause has shifted from rheumatic heart disease to degenerative etiologies.
- Presentation and diagnosis differ from isolated valve disease.
Purpose of the Study:
- To review published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease.
- To assess the role of modern transcatheter techniques in treating this condition.
Main Methods:
- Narrative review of existing literature.
- Evaluation of observational data on transcatheter interventions.
Main Results:
- Limited observational data exist, indicating feasibility but lacking robust guidance.
- Transcatheter aortic valve replacement and edge-to-edge mitral valve repair are feasible.
- These interventions may reduce risks associated with open-heart surgery.
Conclusions:
- Combined aortic and mitral valve disease is a common clinical challenge.
- Transcatheter interventions have a potential role, supported by preliminary data.
- Further research is essential to establish definitive treatment guidelines.
Purpose Of Review:
The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques.
Recent Findings:
Up to a quarter of symptomatic adult valvular disease is caused by multiple left-sided valvular lesions. The etiologic spectrum of this combined disease has shifted from rheumatic to degenerative. Both presentation and diagnosis of lesions are modified compared with isolated disease. Based upon narrative review, there are only limited observational experiences, insufficient to provide robust guidance. These data, however, indicate the feasibility of interventions such as transcatheter aortic valve replacement and edge-to-edge mitral valve repair to treat such disease and mitigate the risks of open surgery. Combined aortic and mitral valve disease is commonly encountered. There is a role for transcatheter interventions based on limited data; however, more research is needed.
More Related Videos
Related Concept Videos
08:31A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
06:59Improved Registration of 3D CT Angiography with X-ray Fluoroscopy for Image Fusion During Transcatheter Aortic Valve Implantation
07:41Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:46Automatic Surgery in Transcatheter Aortic Valve Replacement Using Augmented Reality
09:57Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:13Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve