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Related Concept Videos

Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

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Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
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Standardized, comprehensive and fully quantitative testing of autonomic functions is described. The autonomic tests consist of evaluation of all three major autonomic domains including cardiovagal, adrenergic and sudomotor. The severity and distribution of dysautonomia is quantitated using Composite Autonomic Severity Scores.
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Related Experiment Video

Updated: Jan 19, 2026

Restless Leg Syndrome and Night Terrors
01:27

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Autonomic dysfunction in restless legs syndrome.

Yuksel Erdal1, Ozlem Akdogan2, Mecbure Nalbantoglu3

  • 1Department of Neurology, Istanbul Training and Research Hospital, Kasap İlyas Mah. Org. Abdurrahman Nafiz Gürman Cd. PK: 34098 Fatih, Istanbul, Turkey. erdalyuksel_355@hotmail.com.

Sleep & Breathing = Schlaf & Atmung
|September 15, 2019
PubMed
Summary

Restless legs syndrome (RLS) patients exhibit significant autonomic dysfunction, particularly in cardiovascular, gastrointestinal, and urinary systems, as shown by RR interval variability and SCOPA-AUT scores. Further investigation into RLS autonomic involvement is crucial.

Keywords:
Autonomic dysfunctionRR interval variability, SCOPA-AUTRestless legs syndromeSympathetic skin response

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Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Autonomic dysfunction is increasingly recognized in restless legs syndrome (RLS), but comprehensive electrophysiological and clinical data remain limited and sometimes conflicting.
  • Previous studies suggest potential autonomic nervous system (ANS) involvement in RLS, necessitating further detailed investigation.

Purpose of the Study:

  • To electrophysiologically and clinically evaluate autonomic functions in patients diagnosed with restless legs syndrome (RLS).
  • To compare autonomic function parameters between RLS patients and healthy controls.

Main Methods:

  • Prospective study involving 52 adult RLS patients and 40 healthy controls.
  • Electrophysiological assessments included sympathetic skin response (SSR) and RR interval variability (RRIV) analysis.
  • Clinical autonomic function was assessed using the SCOPA-AUT questionnaire.

Main Results:

  • While SSR showed no significant differences, RRIV analyses revealed significant alterations in RLS patients during rest, deep breathing, and Valsalva maneuvers.
  • RLS patients reported higher SCOPA-AUT scores, indicating greater autonomic dysfunction, especially in gastrointestinal, urinary, and cardiovascular domains.
  • No significant differences were observed in pupillomotor, thermoregulatory, or sexual function domains.

Conclusions:

  • Autonomic dysfunction, particularly cardiac, gastrointestinal, and urinary issues, is prevalent in RLS patients.
  • Autonomic function assessment should be an integral part of evaluating RLS patients alongside motor and sensory symptoms.
  • These findings highlight the need for increased clinical attention to autonomic dysfunction in RLS management.