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Updated: Jan 19, 2026

Designing Silk-silk Protein Alloy Materials for Biomedical Applications
Published on: August 13, 2014
Diverse metabolites from corn silk with anti-Aβ1-42 aggregation activity
Wei-Yu Zhou1, Li-Li Lou1, Rui Guo1
1Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Abstract:
Five pairs of enantiomeric compounds (1a/1b-5a/5b) including seven undescribed compounds (1a/1b-3a/3b, 4b) along with two known ones (. and .) have been isolated from corn silk (Stigma maydis). Racemic mixtures of these enantiomers were separated by HPLC with different types of chiral columns. Their structures were elucidated based on comprehensive spectroscopic analyses together with quantum chemical calculations of 13C NMR data and electronic circular dichroism (ECD) curves. All the isolates were evaluated for their inhibition ability of self-induced Aβ1-42 aggregation. Among them, compounds 4a (88.36%), 4b (74.66%) and . (85.65%) showed stronger inhibitory activity than the positive control curcumin (61.90%). The different inhibition profiles of enantiomers 4a and 4b were explained by docking simulation studies.
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ExpandBefore the experiment, first ensure that the student computers have Microsoft Excel or Google Sheets installed.
If using Excel, make sure the data analysis tool pack is loaded.
Next, you will need to identify the two fields where the students will take measurements. Both fields should ideally have lengths in any direction of at least 30 meters. One field should be a shrubby or weedy field that has not been mowed recently. The second field...
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To begin, divide into...