Parathyroid hormone response to different vitamin D levels in population-based old and very-old Polish cohorts

Low vitamin D (VD) is not always followed by the development of secondary hyperparathyroidism (SHPT). The study aimed to assess the prevalence of SHPT and functional hypoparathyroidism (FHPT) in relation to VD deficiency/insufficiency and factors predisposing to parathyroid hormone (PTH) response in old and very-old Caucasians.

A sub-study of the cross-sectional PolSenior project analyzed serum 25(OH)D, intact PTH (iPTH) and C-terminal fibroblast growth factor 23 (cFGF23) concentrations in 3472 (1658 women) individuals aged ≥65 years. SHPT was defined as iPTH concentration > 65 pg/mL, while FHPT as iPTH within the reference range in the presence of 25(OH)D < 30 ng/mL.

SHPT was diagnosed in 426 participants (14%) and was more frequent in very-old (≥ 80 years) than in the old (65-79 years) subgroup (18.8 vs 9.8%; OR = 2.12; 95% CI: 1.72-2.62). While, FHPT was found in 2269 subjects (85.2%) with 25(OH)D < 30 ng/mL, and was more prevalent in the old than very-old subgroup (89.3 vs 80.1%; OR = 2.03; 95% CI: 1.63-2.52). Multiple regression analysis showed that age ≥ 80 years, use of loop diuretics, decreased glomerular filtration rate, higher cFGF23 level but lower calcium and phosphate concentrations, predispose for the occurrence of SHPT.

The interrelation between 25(OH)D deficiency and PTH response is complex. In older adults, PTH response is related to VD deficiency, age, impaired kidney function, the use of loop diuretics and the levels of calcium, phosphate, and cFGF23.