Molecular characterization and clinical relevance of m⁶A regulators across 33 cancer types

The methylation of N⁶ adenosine (m⁶A) plays a critical role in diverse biological processes. However, knowledge regarding the reconstitution of m⁶A across cancer types is still lacking. Here, we systematically analyzed the molecular alterations and clinical relevance of m⁶A regulators across > 10,000 subjects representing 33 cancer types. We found that there are widespread genetic alterations to m⁶A regulators, and that their expression levels are significantly correlated with the activity of cancer hallmark-related pathways. Moreover, m⁶A regulators were found to be potentially useful for prognostic stratification, and we identified IGF2BP3 as a potential oncogene across multiple cancer types. Our results provide a valuable resource that will guide both mechanistic and therapeutic analyses of the role of m⁶A regulators in cancer.