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Related Experiment Video

Updated: Jan 19, 2026

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
09:17

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[Rebreathing method for measuring CO transfer factor in children].

J Taytard1, P Boizeau2, C Alberti3

  • 1AP-HP, hôpital Trousseau, service de pneumologie pédiatrique, Paris, France; Université Pierre et Marie-Curie-Paris 6, Inserm U938, Paris, France.

Revue Des Maladies Respiratoires
|September 16, 2019
PubMed
Summary

The rebreathing method (rb) for measuring diffusing capacity of the lung for carbon monoxide (DLco) is feasible in children and shows high correlation with the standard single-breath (sb) method. This suggests DLCOrb may be a valuable clinical tool for pediatric lung function testing.

Keywords:
ApnéeCO diffusionCapacité de transfert du COChildrenEnfantInterstitial lung diseasePathologie Interstitielle diffuseRebreathingRéinspirationSingle breath

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Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Clinical Diagnostics

Background:

  • The single-breath method (sb) is the standard for measuring diffusing capacity of the lung for carbon monoxide (DLco).
  • The rebreathing method (rb) offers an alternative for patients unable to perform the sb method.
  • The clinical utility of DLCOrb, particularly in children, requires further evaluation.

Purpose of the Study:

  • To assess the feasibility of the DLCOrb method in a pediatric clinical setting.
  • To evaluate the relationship between DLCOrb and the established DLCOsb method in children.
  • To explore the potential clinical relevance of DLCOrb in pediatric respiratory diagnostics.

Main Methods:

  • Prospective study including children with suspected interstitial lung disease (ILD) and healthy controls.
  • DLCOsb and DLCOrb measurements were performed in the ILD group.
  • DLCOrb was measured using a rebreathing bag, analyzing CO and Helium concentrations.
  • DLCOrb/KCOrb expected values were derived in the asthma control group.

Main Results:

  • DLCOrb measurements were successfully obtained in 91% of children in both ILD and control groups.
  • High correlations were observed between raw DLCOrb and DLCOsb (rhô=0.82) and between KCOrb and KCOsb (rhô=0.62).
  • Moderate correlations were found for percentage predicted values (DLCO: rhô=0.55; KCO: rhô=0.51).

Conclusions:

  • The DLCOrb method is easily performable in pediatric populations.
  • DLCOrb measurements demonstrate a high correlation with DLCOsb values.
  • Preliminary findings support the potential clinical application of DLCOrb in children, pending further validation.