Related Experiment Video
Updated: Jan 19, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
Corticotomy-Assisted Orthodontics for Canine Distalization: A Systematic Review and Meta-Analysis of Clinical
Nouf Zimmo1, Muhammad H A Sal2, Khaled Sinjab2
1Department of Periodontics, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA.
Abstract:
Numerous treatment modalities have been developed to expedite orthodontic treatment time, which improves patient compliance and reduces the likelihood of complications. Corticotomy-assisted orthodontia (CAO) is one procedure that was reported to be highly promising. An electronic search of PubMed and Embase in addition to a search of peer reviewed journals up to December 1st, 2016 was performed. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) guidelines. Quantitative assessment was performed on the articles that fell within the inclusion criteria. Eight randomized controlled trials (RCTs) were included. Weighted mean differences (WMD) of the amount of canine movement (mm) were calculated between the CAO group (test) and the conventional orthodontic group (control) at different follow-up periods. The WMD of canine movement after 2 weeks was 0.58 mm, and after 1 month was 0.83 mm. In longer follow-ups, the WMD after 2 months was 1.17 mm, and after 3 months was 1.61 mm. Results comparing the test and control groups in all time periods favored the CAO groups for complete canine retraction. No signifi cant adverse effects on the periodontium were reported at any of the treatment phases. CAO facilitates complete maxillary canine distalization up to 3 months, and can reduce the overall treatment time by 50%.
Related Concept Videos
08:36The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials
04:34Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Statistical Software for Data Analysis and Clinical Trials
09:09In Silico Clinical Trials for Cardiovascular Disease

