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Related Experiment Video

Updated: Jan 19, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

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Auditory function and dysfunction: estrogen makes a difference.

Amandine Delhez1,2, Philippe Lefebvre2, Christel Péqueux3

  • 1GIGA-Neurosciences, Developmental Neurobiology Unit, University of Liege, Liege, Belgium.

Cellular and Molecular Life Sciences : CMLS
|September 16, 2019
PubMed
Summary
This summary is machine-generated.

Estrogen plays a key role in hearing. While higher estrogen levels correlate with better hearing, menopausal hormone therapy shows mixed results for hearing loss prevention.

Keywords:
CochleaDeafnessEstradiolNeuroprotectionOtoprotectionSexual dimorphismSteroid

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Otolaryngology

Background:

  • Estrogen, a primary female hormone, influences reproductive functions and non-reproductive organs.
  • Emerging evidence suggests estrogen impacts audition and may offer protection against acquired hearing loss.

Purpose of the Study:

  • To review preclinical and clinical studies on sex differences and estrogen's influence on hearing.
  • To explore estrogen's protective mechanisms against various forms of hearing loss.

Main Methods:

  • Review of existing preclinical and clinical research.
  • Analysis of experimental evidence on estrogen's role in hearing.
  • Discussion of potential molecular mechanisms in the cochlea.

Main Results:

  • Higher endogenous estrogen levels are linked to better hearing function.
  • Hormonal treatments during menopause have yielded inconsistent outcomes for hearing preservation.
  • Factors like treatment regimen and patient hormonal status influence treatment efficacy.

Conclusions:

  • Estrogen signaling complexity is under investigation, with identified genomic and non-genomic actions.
  • Understanding estrogen's protective mechanisms in the cochlea is crucial for addressing age-related, drug-induced, and noise-induced hearing loss.