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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Elevated plasma S100A1 level is a risk factor for ST-segment elevation myocardial infarction and associated with
Linlin Fan1,2, Baoxin Liu2, Rong Guo2
1Institute of Biomedical Sciences, Department of Cardiology, Shanghai Institute of Cardiovascular Disease, Fudan University, Shanghai, 200032, China.
Insights
Elevated plasma S100A1 levels are a significant predictor of ST-segment elevation myocardial infarction (STEMI). Higher S100A1 concentrations are associated with increased STEMI risk and impaired cardiac function post-infarction.
Area of Science:
- Cardiology
- Biomarker Research
- Acute Coronary Syndromes
Background:
- ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular event.
- Identifying reliable biomarkers for STEMI prediction and prognosis is crucial for patient management.
Purpose of the Study:
- To investigate the association between plasma S100A1 levels and STEMI.
- To assess the potential role of S100A1 in predicting cardiac function after myocardial infarction.
Main Methods:
- Plasma S100A1 levels were measured in 207 STEMI patients and 217 healthy controls.
- Correlation analysis was used to examine relationships with other cardiac biomarkers.
- Multivariate logistic regression assessed the predictive value of S100A1 for STEMI occurrence and cardiac function.
Main Results:
- STEMI patients exhibited significantly higher plasma S100A1 levels compared to controls (P<0.001).
- S100A1 showed significant correlations with hs-cTnT, CK-MB, LVEF, NT-proBNP, and hs-CRP.
- Elevated S100A1 (> 1965.9 pg/mL) was an independent predictor of STEMI (OR: 6.925) and associated with poorer cardiac function.
Conclusions:
- Elevated plasma S100A1 is a significant predictor of STEMI.
- S100A1 may serve as a valuable biomarker reflecting cardiac function post-acute coronary ischemia.
Aim:
To investigate the association between plasma S100A1 level and ST-segment elevation myocardial infarction (STEMI) and potential significance of S100A1 in post-infarction cardiac function.
Methods:
We examined the plasma S100A1 level in 207 STEMI patients (STEMI group) and 217 clinically healthy subjects for routine physical examination without a history of coronary artery disease (Control group). Baseline characteristics and concentrations of relevant biomarkers were compared. The relationship between S100A1 and other plasma biomarkers was detected using correlation analysis. The predictive role of S100A1 on occurrence of STEMI was then assessed using multivariate ordinal regression model analysis after adjusting for other covariates.
Results:
The plasma S100A1 level was found to be significantly higher (P<0.001) in STEMI group (3197.7±1576.0 pg/mL) than in Control (1423.5±1315.5 pg/mL) group. Furthermore, the correlation analysis demonstrated plasma S100A1 level was significantly associated correlated with hypersensitive cardiac troponin T (hs-cTnT) (r = 0.32; P < 0.001), creatine kinase MB (CK-MB) (r = 0.42, P < 0.001), left ventricular eject fraction (LVEF) (r = -0.12, P = 0.01), N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (r = 0.61; P < 0.001) and hypersensitive C reactive protein (hs-CRP) (r = 0.38; P < 0.001). Moreover, the enrolled subjects who with a S100A1 concentration ≤ 1965.9 pg/mL presented significantly better cardiac function than the rest population. Multivariate Logistic regression analysis revealed that S100A1 was an independent predictor for STEMI patients (OR: 0.671, 95% CI 0.500-0.891, P<0.001). In addition, higher S100A1 concentration (> 1965.9 pg/mL) significantly increased the risk of STEMI as compared with the lower level (OR: 6.925; 95% CI: 4.15-11.375; P<0.001).
Conclusion:
These results indicated that the elevated plasma S100A1 level is an important predictor of STEMI in combination with several biomarkers and also potentially reflects the cardiac function following the acute coronary ischemia.
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