Related Experiment Video
Updated: Jan 19, 2026

Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model
Published on: October 20, 2023
Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
Lefeng Wang1, Weiqiang Lin1,2, Jianghua Chen1
1The Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Abstract:
Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor highly expressed in the glomeruli and interstitial cells of kidneys. An increasing number of studies have demonstrated a critical role for KLF15 in the kidney, involving tubular physiology, podocyte injury, renal fibrosis, and mesangial pathology. In this review, we discuss recent advances and update our overview of the functions of KLF15 in kidney biology, hoping to provide new perspectives on the progression and therapy of Chronic Kidney Disease (CKD). A better understanding of KLF15 with respect to its diverse roles in specific cells or diseases will be beneficial in pursuing novel therapeutic targets and moving forward to precision medicine.
More Related Videos
Related Concept Videos
06:19Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
16:26Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
10:51A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
Therapeutic Drug Monitoring: Affecting Factors
09:16Assessment of Kidney Function in Mouse Models of Glomerular Disease
11:29Technique to Target Microinjection to the Developing Xenopus Kidney

