Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer

Area of Science:

• Oncology
• Hematology

Background:

• Cervical cancer poses a significant global health threat to women.
• Platelet (PLT)-related parameters are linked to cancer prognosis.

Purpose of the Study:

• To investigate the association between platelet parameters and cervical cancer outcomes.
• To determine the prognostic value of pretreatment and post-radiotherapy platelet levels.

Main Methods:

• 110 cervical carcinoma patients were analyzed.
• Patients were grouped based on receiver operating characteristic (ROC) analysis cutoff values for PLT, MPV, PCT, and PDW.
• Post-/preradiotherapy ratios were calculated for platelet parameters.

Main Results:

• Higher pretreatment platelet count correlated with advanced FIGO stage and worse progression-free survival (PFS) and overall survival (OS).
• Increased post-/preradiotherapy platelet ratio was associated with worse PFS and OS.
• Changes in PCT, MPV, or PDW did not affect PFS or OS.

Conclusions:

• Pretreatment platelet count is a significant prognostic factor for cervical cancer.
• The ratio of post-/preradiotherapy platelet levels independently predicts patient outcomes.