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Updated: Jan 19, 2026

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
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Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure

Published on: September 19, 2019

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Rare Conduction Abnormality in a Four-year-old Child with Carbamazepine Acute Poisoning

Cristina Iolanda Vivisenco1, Coriolan Emil Ulmeanu1

  • 1"Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania.

Maedica
|September 17, 2019
PubMed

Insights

Carbamazepine poisoning in children can cause reversible synoatrial block, a cardiac conduction abnormality. Electrocardiogram monitoring is crucial for assessing and managing pediatric carbamazepine toxicity.

Area of Science:

  • Pediatric Cardiology
  • Clinical Toxicology
  • Pharmacology

Background:

  • Cardiac conduction abnormalities are known complications of carbamazepine overdose.
  • This report details a pediatric case of carbamazepine poisoning with associated neurological and cardiac findings.

Discussion:

  • Sinoatrial block, a rare cardiac event, was observed in a 4-year-old child with acute carbamazepine poisoning.
  • While carbamazepine-induced sinoatrial block is documented in adults, this is the first reported instance in pediatric acute poisoning.
  • The patient's serum carbamazepine level was near the upper limit of the therapeutic range, highlighting potential toxicity even within expected levels.

Key Insights:

  • Acute carbamazepine poisoning can manifest as reversible synoatrial block in children.
  • Neurological symptoms often accompany cardiac conduction abnormalities in pediatric carbamazepine toxicity.
  • Electrocardiogram (ECG) is essential for diagnosing and monitoring cardiac effects in pediatric carbamazepine poisoning.

Outlook:

  • Further research is needed to understand the specific mechanisms and prevalence of carbamazepine-induced cardiac conduction abnormalities in pediatric populations.
  • Establishing clear guidelines for ECG monitoring in pediatric carbamazepine poisoning cases is recommended.
  • This case underscores the importance of considering cardiac toxicity in the management of carbamazepine overdose in children.

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