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Synergistic Photobiomodulation with a Dual-Wavelength Laser in an In Vitro Disease Model
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Photobiomodulation via multiple-wavelength radiations.

Andrezza Maria Côrtes Thomé Lima1, Luiz Philippe da Silva Sergio2, Adenilson de Souza da Fonseca2,3

  • 1Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro, 87, Vila Isabel, Rio de Janeiro, 20551030, Brazil. andrezza_mct@hotmail.com.

Lasers in Medical Science
|September 17, 2019
PubMed
Summary

Combining different light radiations for photobiomodulation enhances biological effects like cell proliferation. This approach offers a novel method for therapeutic applications by targeting superficial and deep tissues effectively.

Keywords:
LEDLow power laserMulti-wavelengthPhotobiomodulation

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Area of Science:

  • Biomedical Optics
  • Photomedicine
  • Cell Biology

Background:

  • Photobiomodulation (PBM) uses light to stimulate cellular processes.
  • Single-radiation PBM has established effects, but combinations may offer enhanced outcomes.
  • Understanding combined radiation effects is crucial for optimizing PBM therapies.

Purpose of the Study:

  • To review the literature on photobiomodulation using combined radiation sources.
  • To analyze the effects and applications of multi-radiation PBM.
  • To explore the mechanisms behind combined radiation efficacy.

Main Methods:

  • Literature search of PubMed database.
  • Inclusion criteria: studies within 50 years, English language.
  • Studies included human and animal models, healthy and pathologic conditions.

Main Results:

  • Multiple studies demonstrate varied effects of combined radiations on biological tissues.
  • Enhanced cell proliferation and differentiation observed compared to single radiation.
  • Differential absorption of multiple wavelengths allows targeting of superficial and deep tissues.

Conclusions:

  • Combining different radiation types in photobiomodulation can yield superior biological effects.
  • Multi-wavelength PBM, particularly using low-power lasers and LEDs, presents a promising therapeutic approach.
  • This strategy may enhance treatment efficacy by optimizing light absorption in diverse tissue depths.