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A high platform can fix rats without restriction and completely expose the acupoints on the back during acupuncture manipulation. This article describes methods for the fabrication of the high platform, establishes a rat model of asthma and measures changes in respiratory function using a noninvasive and real-time whole-body plethysmography (WBP)...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma: Pathogenesis and Management01:20

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Acupuncture in a Rat Model of Asthma
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Eosinophilic otitis media and comorbid asthma.

Yukako Seo1, Manabu Nonaka1, Ruby Pawankar2

  • 1Department of Otolaryngology, Tokyo Women's Medical University.

Current Opinion in Allergy and Clinical Immunology
|September 17, 2019
PubMed
Summary

Eosinophilic otitis media (EOM), linked to asthma, requires tailored treatments. Effective management involves controlling asthma and using therapies specific to EOM severity, from topical steroids to surgery.

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Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Eosinophilic otitis media (EOM) is a severe middle ear inflammation with significant eosinophil infiltration.
  • EOM frequently co-occurs with asthma, suggesting a shared pathophysiology under the 'one airway, one disease' concept.

Purpose of the Study:

  • To review the characteristics of EOM.
  • To explore the relationship between EOM and asthma.
  • To evaluate the efficacy of current EOM treatments.

Main Methods:

  • Literature review summarizing current knowledge on EOM.
  • Analysis of the correlation between asthma severity and EOM development.
  • Assessment of treatment strategies based on EOM severity.

Main Results:

  • Asthma severity directly correlates with EOM development; inadequate asthma control exacerbates EOM.
  • Topical steroids are effective for mild EOM, while moderate cases require systemic steroids.
  • Severe EOM with granulation tissue may necessitate surgical intervention; targeted therapies are under investigation.

Conclusions:

  • EOM and asthma share a strong etiological link.
  • Optimizing asthma management is crucial for effective EOM treatment.
  • Treatment approaches for EOM must be individualized according to disease severity.