Related Experiment Video
Updated: Jan 19, 2026
Introduction to Vital Signs
Sudden unresponsive patient with normal vital signs: what is going on?
Lisa Smit1, Kelly A Foks2, Jeannette Hofmeijer3,4
1Department of Intensive Care Adults.
Purpose Of Review:
To summarize the differential diagnosis and diagnostic approach of sudden unresponsiveness with normal vital signs in various settings, including the ICU.
Recent Findings:
Sudden unresponsiveness may be either transient or persistent, and may result from primary brain diseases or nonstructural systemic conditions. Life-threatening causes should always be discriminated from those more benign. Regional epidemiology, for example regarding intoxications, and evolving therapeutic management, for example for ischemic stroke, should always be taken into account for optimal opportunity for rapid diagnosis and best management.
Summary:
Sudden unresponsiveness with normal vital signs should trigger immediate and focused diagnostic evaluation to find or exclude those conditions requiring urgent, and possibly life-saving, management.
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