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Updated: Jan 19, 2026

A Porcine Corneal Endothelial Organ Culture Model Using Split Corneal Buttons
Published on: October 6, 2019
Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects
Mario Matthaei1, Agathe Hribek1, Thomas Clahsen1
1Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany; email: mario.matthaei@uk-koeln.de, agathe.hribek@uk-koeln.de, thomas.clahsen@uk-koeln.de, bjoern.bachmann@uk-koeln.de, claus.cursiefen@uk-koeln.de.
Abstract:
Fuchs endothelial corneal dystrophy (FECD) is a bilateral corneal endothelial disorder and the most common cause of corneal transplantation worldwide. Professor Ernst Fuchs described the first 13 cases of FECD more than 100 years ago. Since then, we have seen far-reaching progress in its diagnosis and treatment. In the field of diagnostics, new technologies enable the development of more accurate classification systems and the more detailed breakdown of the genetic basis of FECD. Laboratory studies help in deciphering the molecular pathomechanisms. The development of minimally invasive surgical techniques leads to a continuous improvement of the postoperative result. This review highlights and discusses clinical, genetic, pathophysiologic, and therapeutic aspects of this common and important corneal disorder.
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