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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)08:46

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Related Experiment Video

Updated: Jan 19, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
08:46

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Latest developments in post-mortem foetal imaging.

Susan C Shelmerdine1,2,3, John C Hutchinson1,2,3, Owen J Arthurs1,2,3

  • 1Department of Radiology Great Ormond Street Hospital for Children NHS Foundation Trust London, London, UK.

Prenatal Diagnosis
|September 17, 2019
PubMed
Summary
This summary is machine-generated.

Declining autopsy consent drives development of advanced imaging techniques for perinatal death investigation. Post-mortem MRI and CT offer promising, less-invasive alternatives for fetal examination and diagnosis.

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Last Updated: Jan 19, 2026

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Area of Science:

  • Medical Imaging
  • Perinatal Pathology
  • Forensic Science

Background:

  • Declining parental consent rates for perinatal autopsies necessitate alternative death investigation methods.
  • Traditional autopsies are being supplemented by less-invasive techniques for perinatal death investigation.

Purpose of the Study:

  • To review current and emerging imaging techniques for perinatal death investigation.
  • To explore the role of advanced imaging in diagnosing fetal conditions without autopsy data.

Main Methods:

  • Review of post-mortem imaging modalities including MRI, CT, and ultrasound.
  • Discussion of minimally invasive techniques like image-guided biopsies and laparoscopy.
  • Exploration of advanced MRI biomarkers (diffusion-weighted imaging, volumetric analysis).

Main Results:

  • High-field MRI and micro-focus CT show promise for early gestation fetuses.
  • MRI biomarkers can aid diagnosis when autopsy data is unavailable.
  • 3D printing and augmented reality can enhance accessibility of imaging findings.

Conclusions:

  • Advanced imaging techniques are crucial for modern perinatal death investigation.
  • These methods provide valuable diagnostic information, especially with declining autopsy rates.
  • Emerging technologies promise improved understanding and communication of findings.