Recent progress in the small-molecule fluorescent probes for the detection of sulfur dioxide derivatives...

Sulfur dioxide (SO₂) had been recognized as an environmental pollutant produced from industrial processes. SO₂ is water soluble and forms hydrated SO₂ (SO₂·H₂O), bisulfite ion (HSO₃^-), and sulfite ion (SO₃^2-) upon dissolution in water. SO₂ could be also produced endogenously from sulfur-containing amino acids l-cysteine in mammals. Endogenous SO₂ can maintain the balance of biological sulfur and redox equilibrium in vivo, regulate blood insulin levels and reduce blood pressure. Excess intake of exogenous SO₂ can result in respiratory diseases, cardiovascular diseases and neurological disorders. As a result, fluorescent probes to detect HSO₃^-/SO₃^2- have attracted great attention in recent years. Herein, a general overview was provided with the aim to highlight the typical examples of the HSO₃^-/SO₃^2- fluorescent probes reported since 2010, especially those in the past five years. We have classified HSO₃^-/SO₃^2- fluorescent probes through different chemical reaction mechanisms and wish this review will give some help to the researchers in this field.