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Related Concept Videos

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Related Experiment Video

Updated: Jan 19, 2026

Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices
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Is Contrast Stasis After Pipeline Embolization Device Deployment Associated with Higher Aneurysm Occlusion Rates?

Kunal Vakharia1, Muhammad Waqas1, Stephan A Munich1

  • 1Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA; Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, New York, USA.

World Neurosurgery
|September 17, 2019
PubMed
Summary

Immediate contrast stasis after Pipeline Embolization Device (PED) placement for intracranial aneurysms (IAs) does not predict long-term occlusion rates. This finding suggests other factors are more critical for successful IA treatment outcomes.

Keywords:
Aneurysm occlusionContrast stasisPipeline embolization device

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Area of Science:

  • Neuroendovascular surgery
  • Cerebrovascular diseases
  • Medical device technology

Background:

  • Intracranial aneurysms (IAs) pose significant risks, necessitating effective treatment strategies.
  • The Pipeline Embolization Device (PED) is a common endovascular treatment for IAs.
  • Assessing immediate post-deployment factors is crucial for predicting treatment success.

Purpose of the Study:

  • To evaluate the relationship between immediate post-deployment contrast stasis in intracranial aneurysms (IAs) treated with the Pipeline Embolization Device (PED).
  • To determine if the degree of contrast stasis correlates with 6- and 12-month angiographic occlusion rates.
  • To identify potential predictors of successful IA occlusion after PED treatment.

Main Methods:

  • Retrospective cohort study of patients undergoing PED deployment for saccular IA treatment.
  • Angiographic grading of intra-aneurysmal contrast flow immediately after PED deployment (0-3 scale).
  • Follow-up angiography at 6 and 12 months to assess occlusion rates.

Main Results:

  • 119 patients with 141 aneurysms treated with 182 PEDs were analyzed.
  • Immediate contrast stasis grades (0-3) were observed in 139 aneurysms.
  • No statistically significant association was found between immediate contrast stasis grades and 6- or 12-month complete occlusion rates (P=0.60).

Conclusions:

  • The degree of immediate contrast stasis following PED deployment does not statistically predict 6- and 12-month angiographic occlusion rates for intracranial aneurysms.
  • Factors beyond immediate contrast flow appear to influence long-term treatment success.
  • Further research may be needed to identify other predictive markers for successful PED treatment.