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GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis

Linghui Zhou1, Shanshan Dong2, Yujiao Deng1

  • 1Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Molecular Therapy. Nucleic Acids
|September 17, 2019
PubMed

Insights

This study links TYMS (rs1059394) gene variations to glioma risk and GOLGA7 (rs11337) variations to glioma patient survival in the Chinese Han population.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) regulate gene expression and are implicated in tumorigenesis.
  • Genetic variations in miRNA-related genes can influence cancer susceptibility and outcomes.
  • Glioma is a common primary brain tumor with significant mortality.

Purpose of the Study:

  • To investigate the association between single-nucleotide polymorphisms (SNPs) in TYMS, RYR3, KIAA0423, and GOLGA7 genes and glioma risk.
  • To evaluate the impact of these SNPs on the prognosis of glioma patients.

Main Methods:

  • Case-control study involving 605 glioma patients and 1,300 controls from the Chinese Han population.
  • Genotyping of five SNPs: TYMS (rs1059394, rs2847153), RYR3 (rs1044129), KIAA0423 (rs1053667), and GOLGA7 (rs11337).
  • Statistical analyses including logistic regression, Kaplan-Meier, log rank tests, and Cox regression were employed.

Main Results:

  • The TYMS rs1059394 polymorphism was significantly associated with increased glioma susceptibility in homozygote and dominant models.
  • The GOLGA7 rs11337 GG genotype was correlated with better overall survival in glioma patients compared to the GT genotype.
  • Cox regression analysis indicated that the GOLGA7 rs11337 GT genotype was a predictor of worse overall survival.

Conclusions:

  • The TYMS rs1059394 polymorphism may contribute to glioma risk in the studied population.
  • The GOLGA7 rs11337 polymorphism is a potential prognostic marker for glioma patients, influencing overall survival.
Keywords:
GOLGA7cancer riskmicroRNA-binding sitepolymorphismprognosisrs11337

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