Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inducing Brain Death in a Mouse Model Using a Balloon Catheter02:06

Inducing Brain Death in a Mouse Model Using a Balloon Catheter

623
This video demonstrates the procedure for inducing brain death in a mouse model by increasing controlled intracranial pressure through a balloon catheter, mimicking natural brain...
623
Routh-Hurwitz Criterion I01:15

Routh-Hurwitz Criterion I

553
Consider an electrical power grid, where stability is essential to prevent blackouts. The Routh-Hurwitz criterion is a valuable tool for assessing system stability under varying load conditions or faults. By analyzing the closed-loop transfer function, the Routh-Hurwitz criterion helps determine whether the system remains stable.
To apply the Routh-Hurwitz criterion, a Routh table is constructed. The table's rows are labeled with powers of the complex frequency variable s, starting from the...
553
Routh-Hurwitz Criterion II01:19

Routh-Hurwitz Criterion II

971
In the application of the Routh-Hurwitz criterion, two specific scenarios can arise that complicate stability analysis.
The first scenario occurs when a singular zero appears in the first column of the Routh table. This situation creates a division by zero issues. To resolve this, a small positive or negative number, denoted as epsilon (∈), is substituted for the zero. The stability analysis proceeds by assuming a sign for ∈. If ∈ is positive, any sign change in the first...
971
TUNEL Assay for Detecting Apoptotic Cell Death in a Brain Slice01:30

TUNEL Assay for Detecting Apoptotic Cell Death in a Brain Slice

440
To detect apoptotic cell death using the TUNEL assay, treat the brain slice with the enzyme...
440
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

343
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
343
Potential-Energy Criterion for Equilibrium01:16

Potential-Energy Criterion for Equilibrium

927
Potential energy or potential function plays an essential role in determining the stability of a mechanical system. If a system is subjected to both gravitational and elastic forces, the potential function of the system can be expressed as the algebraic sum of gravitational and elastic potential energy. If the system is in equilibrium and is displaced by a small amount, then the work done on the system equals the negative of the change in the system's potential energy from the initial to the...
927

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Michael P. McQuillen, MD, MA (1932-2025).

Neurology·2026
Same author

Brain Death and Live Birth: History and Bioethics.

The American journal of bioethics : AJOB·2026
Same author

Donor Hearts for Transplantation after Circulatory Death.

The New England journal of medicine·2025
Same author

The Medical Profession Determines Standards for Death Determination.

The American journal of bioethics : AJOB·2025
Same author

The Civil Versus the Neurocentric Conceptions of Death.

The American journal of bioethics : AJOB·2025
Same author

The Necessity of Brain Blood Flow Testing in Thoracoabdominal Normothermic Regional Perfusion.

Transplantation·2025

Related Experiment Video

Updated: Jan 19, 2026

Inducing Brain Death in a Mouse Model Using a Balloon Catheter
02:06

Inducing Brain Death in a Mouse Model Using a Balloon Catheter

623

Aligning the Criterion and Tests for Brain Death.

James L Bernat, Anne L Dalle Ave

    Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees
    |September 19, 2019
    PubMed
    Summary

    Brain death determination requires careful review, as some patients show residual brain function due to diagnostic errors or minimal blood flow. Improving physician training and testing protocols can enhance accuracy in declaring brain death.

    Keywords:
    brain deathbrain death determinationbrain death testswhole brain criterion

    More Related Videos

    TUNEL Assay for Detecting Apoptotic Cell Death in a Brain Slice
    01:30

    TUNEL Assay for Detecting Apoptotic Cell Death in a Brain Slice

    440
    Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy
    05:03

    Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

    Published on: April 17, 2020

    5.9K

    Related Experiment Videos

    Last Updated: Jan 19, 2026

    Inducing Brain Death in a Mouse Model Using a Balloon Catheter
    02:06

    Inducing Brain Death in a Mouse Model Using a Balloon Catheter

    623
    TUNEL Assay for Detecting Apoptotic Cell Death in a Brain Slice
    01:30

    TUNEL Assay for Detecting Apoptotic Cell Death in a Brain Slice

    440
    Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy
    05:03

    Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

    Published on: April 17, 2020

    5.9K

    Area of Science:

    • Neurology
    • Medical Ethics
    • Forensic Medicine

    Background:

    • Recent cases highlight discrepancies where patients declared brain dead exhibit residual brain function.
    • This mismatch challenges the established whole-brain criterion for determining death.

    Purpose of the Study:

    • To investigate the reasons behind the discordance between brain death criteria and testing outcomes.
    • To propose solutions for improving the accuracy of brain death determination.

    Main Methods:

    • Analysis of published cases involving potential diagnostic errors in brain death determination.
    • Review of physiological factors, such as residual cerebral blood flow, that may influence test results.

    Main Results:

    • Diagnostic errors in clinical practice are a significant cause of inaccurate brain death declarations.
    • A small amount of residual blood flow to the brain can occur despite evidence of intracranial circulatory arrest, complicating assessments.

    Conclusions:

    • Enhancing physician training in brain death determination protocols is crucial.
    • Mandating tests that confirm complete cessation of intracranial circulation can improve diagnostic reliability.
    • Revising the current whole-brain criterion may be necessary to address these complex cases.