Related Experiment Video
Updated: Jan 19, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
Utilization of CAR T Cell Therapy in Pediatric Patients
Victoria Szenes1, Kevin J Curran1
1Memorial Sloan Kettering Cancer Center, Department of Pediatrics, New York, NY.
Objective:
To provide an overview of chimeric antigen receptor (CAR) T cell therapy for pediatric patients with relapsed or refractory malignancy and the associated toxicities.
Data Sources:
Research articles, reviews, clinical trial information.
Conclusion:
The key to the successful application of CAR T cell immunotherapy is (1) identifying patients with malignancies that are eligible for immunotherapy, (2) coordinating T-cell collection, (3) safe infusion of CAR T cells, and (4) managing/preventing toxicities following infusion.
Implications For Nursing Practice:
As the use of targeted therapy with tumor-specific T cells becomes more prevalent, it is essential that the nursing staff stay abreast of these current therapies.
Related Concept Videos
12:55Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
08:19A Spheroid Killing Assay by CAR T Cells
Pharmacokinetics in Pediatric Patients: Drug Excretion
05:14Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism

