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Related Experiment Video

Updated: Jan 19, 2026

Infertility in Males
01:23

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Infertility and mortality.

Natalie C Stentz1, Nathanael Koelper1, Kurt T Barnhart1

  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania Perlman School of Medicine, Philadelphia, PA.

American Journal of Obstetrics and Gynecology
|September 19, 2019
PubMed
Summary
This summary is machine-generated.

Infertility history is linked to a higher risk of death from any cause and cancer, particularly in women with a low baseline mortality risk. This highlights the importance of considering infertility in long-term health monitoring.

Keywords:
cancerinfertilitylong-term healthmortality

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Last Updated: Jan 19, 2026

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Area of Science:

  • Reproductive Health and Epidemiology
  • Oncology
  • Gerontology

Background:

  • Infertility affects approximately 10% of reproductive-age women in the US.
  • The long-term health implications of infertility beyond reproductive years are not well understood.

Purpose of the Study:

  • To investigate the association between a history of infertility and all-cause and cause-specific mortality.
  • To identify specific mortality risks associated with infertility in older women.

Main Methods:

  • Secondary analysis of a large multicenter randomized clinical trial (Prostate, Lung, Colorectal, and Ovarian cancer-screening trial).
  • Included 75,784 women aged 55-74 years with a minimum 10-year follow-up.
  • Used Cox-proportional hazard regression models adjusted for disease risk scores to assess mortality risks.

Main Results:

  • Infertile women had a 10% increased risk of all-cause mortality (aHR, 1.10).
  • A 23% increased risk of cancer mortality was observed in infertile women (aHR, 1.23), with a more than doubled risk of breast cancer death in low-risk individuals (aHR, 2.64).
  • Increased mortality risks were most pronounced in women with an initially low risk of death.

Conclusions:

  • Infertility history serves as an indicator for future morbidity and mortality.
  • Infertile women face elevated risks for all-cause and cancer-related mortality.
  • Incorporating infertility history into healthcare can facilitate early screening and intervention for improved long-term health outcomes.