Related Experiment Video
Updated: Jan 19, 2026

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
Published on: March 10, 2016
Evaluation of nasal obstruction in children by acoustic rhinometry: A prospective study
Léa Distinguin1, Bruno Louis2, Geneviève Baujat3
1Oto-rhino-laryngologie et chirurgie cervico-faciale Pédiatrique, Hôpital Necker-Enfants Malades, Paris, France; Faculté de Médecine, Université Paris est, Créteil, France; Inserm U955 eq 13, Créteil, France.
Introduction:
acoustic rhinometry (AR) is a non-invasive method measuring the nasal volume (NV) and the nasal minimal cross-sectional area (MCA), reflecting nasal obstruction. The first objective of this study was to measure and compare NV and MCA between 3 groups of children: "achondroplasia", "Down syndrome" and "control". The control group corresponded to children with suspicion of sleep disorder disease and without cranio-facial malformation. The second objective was to correlate AR measurements with the obstructive apnea-hypopnea index (OAHI).
Methods:
prospective study between February and July 2017, in a tertiary care center. The following data were collected: demographic characteristics, medical and surgical history, NV, MCA, and OAHI.
Results:
83 children were included. The mean NV was lower in achondroplasia group compared to control group: 2.75 cm3 vs 3.60 cm3 (p = 0.02, 95% CI [0.0694, 0.7456]). Negative correlation was found between the NV and the OAHI for children with achondroplasia (T = -0.37; p = 0.02).
Conclusions:
AR is an effective tool for assessing nasal obstruction in children. Nasal obstruction was correlated to OAHI in achondroplasia. AR could become a routine tool in the management of nasal obstruction of children with cranio-facial malformations.
Related Concept Videos
12:08Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
Prospect Theory
08:00Studying Brain Function in Children Using Magnetoencephalography
09:57Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
04:54A Stable Phantom Material for Optical and Acoustic Imaging
08:47Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
