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Hippo signalling during development.

John Robert Davis1, Nicolas Tapon2

  • 1Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Development (Cambridge, England)
|September 19, 2019
PubMed
Summary
This summary is machine-generated.

The Hippo signalling pathway and its transcriptional co-activators (Yorkie/YAP/TAZ) regulate tissue growth. This pathway is crucial for diverse cellular decisions in animal development, including proliferation, death, and cell fate determination.

Keywords:
Cell fateDifferentiationGrowthHippo pathwayMorphogenesisYAP

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • The Hippo signalling pathway and its targets, Yorkie/YAP/TAZ, were initially identified for their role in controlling tissue growth.
  • Over 15 years, research has revealed the Hippo pathway's involvement in various cellular processes beyond growth control.

Purpose of the Study:

  • To outline the core Hippo signalling pathway and its regulatory mechanisms.
  • To describe the diverse roles of the Hippo pathway in animal development.

Main Methods:

  • Literature review and synthesis of existing research on the Hippo signalling pathway.
  • Analysis of the pathway's involvement in cellular decision-making processes.

Main Results:

  • The Hippo pathway, along with its transcriptional co-activators Yorkie/YAP/TAZ, plays a fundamental role in tissue growth.
  • This pathway is a versatile regulator, involved in proliferation, cell death, morphogenesis, and cell fate determination.
  • The Hippo pathway is iteratively utilized across various developmental contexts in animals.

Conclusions:

  • The Hippo signalling pathway is a central regulator of multiple cellular processes critical for animal development.
  • Its multifaceted roles highlight its importance as a 'jack of all trades' in developmental biology.
  • Further understanding of this pathway can provide insights into developmental mechanisms and potential therapeutic targets.