Related Experiment Video
Updated: Jan 19, 2026

MALDI-Mass Spectrometric Imaging for the Investigation of Metabolites in Medicago truncatula Root Nodules
Published on: March 5, 2014
MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid
Giulia Capitoli1, Isabella Piga2, Stefania Galimberti3
1Center of Biostatistics for Clinical Epidemiology, Department of Medicine and Surgery, University of Milano - Bicocca, 20900 Vedano al Lambro, Italy. g.capitoli@campus.unimib.it.
Abstract:
The present study applies for the first time as Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging (MSI) on real thyroid Fine Needle Aspirations (FNAs) to test its possible complementary role in routine cytology in the diagnosis of thyroid nodules. The primary aim is to evaluate the potential employment of MALDI-MSI in cytopathology, using challenging samples such as needle washes. Firstly, we designed a statistical model based on the analysis of Regions of Interest (ROIs), according to the morphological triage performed by the pathologist. Successively, the capability of the model to predict the classification of the FNAs was validated in a different group of patients on ROI and pixel-by-pixel approach. Results are very promising and highlight the possibility to introduce MALDI-MSI as a complementary tool for the diagnostic characterization of thyroid nodules.
Related Concept Videos
09:59MALDI-Mass Spectrometric Imaging for the Investigation of Metabolites in Medicago truncatula Root Nodules
04:23A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
06:16MALDI-ToF MS Method for the Characterization of Synthetic Polymers with Varying Dispersity and End Groups
09:08Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging
08:33An Ex vivo Culture System to Study Thyroid Development
04:14In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

