Hyperbaric Oxygen Therapy as an Elective Treatment

Take a mouse subjected to laser-induced damage to the optic nerve head in the eye.The damage causes endothelial cell injury and blood clot formation in the blood vessels supplying the nerve, reducing blood flow and causing ischemia.Ischemia deprives the retinal ganglion cell axons in the optic nerve head of oxygen.In the RGC cell bodies, this disruption impairs mitochondrial function and increases reactive oxygen species production.The resulting oxidative stress activates apoptotic signaling...

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...

Achilles tendinopathy is a common musculoskeletal condition for which loading programs are currently the standard of care. However, the treatment protocols vary. We therefore propose a protocol for Achilles tendinopathy treatment using extracorporeal shockwave...

Source: Mess, G., et al. Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System. J. Vis. Exp. (2023)This video demonstrates a protocol for performing sonodynamic therapy on a brain tumor in a mouse model using magnetic resonance-guided focused ultrasound (MRgFUS). A sonosensitizer precursor is administered prior to treatment, which accumulates in tumor cells and is activated by focused ultrasound to produce reactive...

We describe guidelines to perform a safe and efficient elective fiberoptic intubation in pediatric patients while maintaining spontaneous...

The presented protocol describes a traditional Chinese medicine treatment procedure known for its safety and effectiveness in managing gestational...