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Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients
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Update on Dual Antiplatelet Therapy for Secondary Stroke Prevention

Alexandria Stringberg1, Ryan Camden1, Kathryn Qualls1

  • 1Alexandria Stringberg, Pharmd, PGY2 Internal Medicine Pharmacy resident; Ryan Camden, PharmD, BCPS, Clinical Pharmacy Specialist - Internal Medicine, PGY-2 Internal Medicine Residency Program Director; Kathryn Qualls, PharmD, BCPS, BCCCP, Clinical Pharmacy Specialist-Neurology; and Syed H. Naqvi, MD, Associate Professor of Clinical Medicine, Division of Hospital Medicine; all at the University of Missouri Health System.

Missouri Medicine
|September 19, 2019
PubMed

Insights

Dual antiplatelet therapy with aspirin and clopidogrel may aid secondary stroke prevention after minor stroke or transient ischemic attack. However, the exact bleeding risk associated with this treatment strategy requires further investigation.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Aspirin is a standard treatment for acute ischemic stroke.
  • Dual antiplatelet therapy (DAPT) shows potential for early secondary stroke prevention.
  • The safety profile of DAPT, particularly bleeding risk, needs clarification.

Purpose of the Study:

  • To review existing literature on DAPT for secondary stroke prevention.
  • To evaluate the benefits of DAPT in minor stroke and transient ischemic attack (TIA).
  • To analyze the risk-benefit balance of DAPT in this patient population.

Main Methods:

  • Literature review of published studies.
  • Analysis of clinical trials and observational data.
  • Focus on studies investigating aspirin and clopidogrel combination therapy.

Main Results:

  • DAPT may offer benefits in secondary prevention for minor stroke/TIA patients.
  • The precise bleeding risk associated with DAPT remains uncertain.
  • Balancing therapeutic benefits against potential bleeding complications is crucial.

Conclusions:

  • DAPT (aspirin and clopidogrel) is a potential strategy for secondary stroke prevention.
  • Further research is needed to precisely quantify bleeding risks.
  • Individualized treatment decisions should weigh the benefits against the risks.

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