Does CNS Myelin Inhibit Axon Regeneration?

Membrane proteins on oligodendrocytes and CNS myelin (NI35/250) have been shown to block axon out-growth in culture, and this is thought to be one of the major reasons for severely limited regeneration of severed axons in the CNS of higher vertebrates. In a recent study, adult dorsal root ganglion (DRG) neurons, which are sensitive to these inhibitory proteins, regenerated successfully after transplantation into two white matter tracts of the rat brain without any intervention to suppress the inhibitory activity of CNS myelin. The results and implications of these two studies are considered.