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Updated: Jan 19, 2026

Postoperative Ileus Murine Model
Published on: July 12, 2024
Sigmoid gallstone ileus: a challenging diagnosis
Renuka Malenie1, Lisa Leone2, Mgf Gilliland2
1East Carolina University Brody School of Medicine, Department of Pathology and Laboratory Medicine. Greenville, North Carolina, USA.
Gallstone ileus, a rare complication of gallstone disease, typically obstructs the small intestine. This case highlights a fatal instance of gallstone ileus causing large bowel obstruction and colonic perforation in an elderly patient.
Area of Science:
- Gastroenterology
- Pathology
- Surgical Case Report
Background:
- Gallstone ileus is a rare complication of gallstone disease, usually causing small bowel obstruction.
- It is more prevalent in elderly patients with comorbidities.
- Large bowel obstruction due to gallstone ileus is exceptionally uncommon.
Observation:
- A 95-year-old woman presented with abdominal pain.
- CT revealed a foreign body in the sigmoid colon, later identified as a gallstone.
- Autopsy confirmed colonic perforation by the impacted gallstone.
Findings:
- The gallstone perforated the sigmoid colon at a site of fibrotic narrowing and diverticula.
- The gallbladder contained a matching stone and showed signs of necrosis.
- Peritonitis secondary to colonic perforation was the cause of death.
Implications:
- This case underscores the potential for gallstones to cause rare forms of gastrointestinal obstruction.
- It highlights the importance of considering gallstone disease in elderly patients with bowel obstruction, even in the large bowel.
- Autopsy findings revealed a unique presentation of gallstone ileus leading to fatal colonic perforation.
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