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Updated: Jan 19, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
HectH9 hijacks glucose metabolism to fuel tumor growth
Hong-Jen Lee1, Jiabei He1, Chia-Hsin Chan1,2
1Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.
Abstract:
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria for activating HK2's functions in glycolysis promotion and apoptosis inhibition, suggesting that targeting HectH9 is a new strategy to tackle metabolism-addicted tumors.
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